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Critical molecular pathways in CLL therapy
Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in western countries, is characterized by the progressive accumulation in blood, bone marrow and lymphoid tissues of monoclonal B lymphocytes with a characteristic immunophenotype. Despite advances in therapy and improved outcome, in most instances CLL is an incurable disorder. Signaling via the B-cell receptor (BCR), the up...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2018
ISSN: 1076-1551,1528-3658
DOI: 10.1186/s10020-018-0001-1